An independent scientific registry·For AI Generated Art(ificial) bio sequences·Operated under the ArtGene Consortium v1.0EN · FR · ES · ZH · JA

ARTGENE CONSORTIUM · VOLUME I · 2026  —  § 01 — Overview

The first public registry for AI-designed biological sequences.

Generative models now produce proteins and genes faster than the scientific community can catalogue them. ArtGene is the infrastructure layer: automated biosafety screening, codon watermarking, post-quantum certificates, and an immutable public ledger; for every sequence.

0
Sequences registered
0
Biosafety gates
0
Partner institutions
0%
Open access

§ 02 — Features

What’s built and what’s next.

10 capabilities are live today. 7 more are in active development. Click any live feature to jump to its interactive demo below.

● LIVE
Every sequence runs gates α, β, γ, δ automatically before a certificate is issued.
● LIVE
Issue fingerprinted copies to recipients. Identify the source of a leaked sequence in milliseconds.
● LIVE
Immutable audit ledger
Blockchain-style SHA3-256 chained log. DB-level trigger prevents any row from being modified.
● LIVE
Each registered sequence receives a permanent, citable accession number (e.g. AG-2026-000001).
● LIVE
Screen multi-FASTA fragments individually and as assembled contigs — catches split-vector evasion.
● LIVE
Per-residue pLDDT scores and instability index from ESMAtlas — folds before certifying.
● LIVE
CAI, GC content, and HGT risk against six host organisms.
● LIVE
Machine-readable attestation document generated per certificate for regulatory submission.
● LIVE
Signed synthesizer authorisation compatible with firmware-level screening.
● LIVE
All certified sequences publicly discoverable by AG-ID, institution, or sequence hash.
◌ IN PIPELINE
DOPRF privacy-preserving pathogen screening and IBBIS HMM family classification.
◌ IN PIPELINE
Amino acid composition fingerprint vs. dangerous-protein reference database.
◌ IN PIPELINE
LWE lattice commitment (real)
Post-quantum zero-knowledge commitment currently stubbed — full implementation in Phase 4.
◌ IN PIPELINE
Merkle inclusion proofs for pathways
Per-sequence membership proofs within a pathway bundle. Phase 7.
◌ IN PIPELINE
SDK: Python, R, Julia
First-party client libraries for programmatic submission and verification.
◌ IN PIPELINE
Rich sequence metadata
Abstract, authors, ORCID, keywords, generating model, and molecular weight per record.
◌ IN PIPELINE
KYC and Benchtop synthesizers ready
Specifications & security approved machine-readable certificates created for Benchtop synthesizers.

§ 03 — Biosafety Pipeline

Four-gate automated biosafety review.

Select a sequence from the test-vector library and run the full analysis. All four gates execute automatically. A certificate is issued only when every gate passes.

5′ATGGTGAGCAAGGGCGAGGAACTGTTCACCGGGGTGGTGCCCATCCTGGTCGAGCTGGACGGCGAC…3′720 bp
Gate α — Structural screening
ESMFold pLDDT + instability index
Gate β — Pathogen screening
SecureDNA DOPRF + IBBIS HMM
Gate γ — Codon optimisation
CAI, GC content, HGT risk (6 hosts)
Gate δ — Embedding similarity
Composition fingerprint vs. reference DB

§ 04 — Watermark & Provenance

TINSEL: certify once, trace forever.

Watermarking is not applied at deposit — it is applied at distribution. Every authorised copy carries a unique spread-spectrum fingerprint invisible at the protein level.

Base sequence — pre-distribution, no watermark
At registration the sequence is stored as-is. Applying a watermark now would be identical for every future recipient — meaningless for tracing.
Certificate — AG-2026-000842
ARTGENE ARCHIVE
Certificate of Registration
AccessionAG-2026-000842
SequenceGFP-variant-β
DepositorGinkgo Bioworks
Issued2026-04-15 14:32 UTC
SignatureWOTS+ / SHA3-256
Distribution copies0 — not yet distributed
SIG: a3f7c2e1b9d4…8f2a1c0e3b7d

§ 05 — Fragment Assembly

Split-vector evasion? Caught.

A bad actor may attempt to split a hazardous sequence across multiple FASTA fragments to evade individual screening. ArtGene screens each fragment alone, then screens the reassembled contig.

POST /api/proxy/analyse/fragments IN PROGRESS
F1ATGGTGAGCAAGGGCGAGGAACTG…240 bp
F2TTCACCGGGGTGGTGCCCATCCTG…240 bp
F3GTCGAGCTGGACGGCGACGTAAAC…240 bp

§ 06 — Compliance & Synthesis Auth

Ready for regulatory submission.

Every certificate generates two machine-readable compliance documents automatically: a US DURC / EU Dual-Use attestation manifest and an ArtGene Synthesis Clearance Document.

DURC-MANIFEST
US DURC + EU Dual-Use
Dual-use research of concern attestation
Subject to DURC policyNo
EU Cat. 2B350 overlapNo
Gain-of-function riskNone detected
Recommended oversightBiosafety Level 1
Generated2026-04-15
AG-SCD-1.0
Synthesis Clearance Document
ArtGene-SCD-1.0 — synthesizer authorisation
Authorisation statusCLEARED
AG-IDAG-2026-000842
Valid for synthesisYes
Compatible firmwareSCD-1.0+
Issued2026-04-15

§ 07 — Registry

Public. Searchable. Immutable.

Every certified sequence is permanently discoverable. The registry is open-access — no account required to search, cite, or verify.

◌ DEMO DATA6 records shown
AG-IDSequenceInstitutionDateStatus
AG-2026-001089CircRNA-RegInstitute A2026-04-22CERTIFIED
AG-2026-001002MembAnchor-v3Institute B2026-04-21CERTIFIED
AG-2026-000956MetabEng-Enz1Independent Researcher X2026-04-20CERTIFIED
AG-2026-000901SynTF-v2Centeral facility C.2026-04-18CERTIFIED
AG-2026-000842GFP-variant-βUniversity U2026-04-15CERTIFIED
AG-2026-000791PhotoSys-ModIndependent Lab L.2026-04-12CERTIFIED

§ 08 — Roadmap

Six phases to full production.

Phases 1 and 2 are complete. Phase 3 is active — partner onboarding and production hardening.

PHASE 1DONE
Foundation
Registry API
TINSEL watermark
Four-gate pipeline
WOTS+ certificates
Audit ledger
PHASE 2DONE
Compliance
DURC manifest
SCD-1.0 document
Fragment assembly screen
Provenance tracing
Pathway bundles
PHASE 3ACTIVE
Scale
Experts onboarding
SecureDNA production
IBBIS v2 integration
Performance benchmarks
Publications
Fundraising
PHASE 4PLANNED
Crypto
·LWE lattice commitment
·ZK proof system
·Full WOTS+ verification
·Merkle pathway proofs
PHASE 5PLANNED
SDK
·Python SDK
·R package
·Julia bindings
·REST SDK v2
PHASE 6PLANNED
Production
·ESM-2 650M embeddings
·Rich metadata
·WebSocket live feed
·Benchtop Synthesizer ready
§ 09 — Get involved

Every AI-designed sequence
must have a chain of custody.

Whether you're a lab depositing sequences, an independent bio explorer , or a developer with ideas to make this better - there's a path for you.

DEPOSITORS
Submit AI-designed sequences for certification and public archiving.
Deposit a sequence →
INSTITUTIONS & RESEARCHERS
Join and contribute to the consortium charter, bridge knowledge-gaps.
Become a partner →
DEVELOPERS
Help building the ArtGene-archive secure and future ready
Sign up →
Run the live demo ↓
An open call

“The infrastructure for AI-designed biology should be built in public, by the people who understand what's at stake.”

ArtGene-archive needs a consortium level effort. If you work at the intersection of synthetic biology, biosecurity, or machine learning, your expertise shapes what this registry becomes. Researchers bring domain knowledge we can't encode alone. Developers push the protocol further than any single team can. Policy makers ensure the governance layer keeps pace with the science. Together we make sure, bio-research becomes equitable & accessible to all.